Biological Control Systems: Systems Biology of Diseases and the Design of Effective Treatments

美国特拉华大学的Babatunde A. Ogunnaike院士来校进行交流。

题目:Biological Control Systems: Systems Biology of Diseases and the Design of Effective Treatments

报告人:Babatunde A. Ogunnaike教授 

时间:2017年9月4日(星期一)下午14:30~17:00
地点:和平楼第二会议室


讲座摘要:

The mammalian organism maintains stable, efficient and “near-optimal” performance and homeostasis in the face of external and internal perturbations via distinct biological systems ranging from the large-scale physiological (nervous, endocrine, immune, circulatory, respiratory, etc.), to the cellular (growth and proliferation regulation, DNA damage repair, etc.), and the sub-cellular (gene expression, protein synthesis, metabolite regulation, etc). “Biological Control Systems,” a sub-topic of Control Theory, arises from a control engineering perspective of the function, organization, and coordination of these multi-scale biological systems and the control mechanisms that enable them to carry out their functions effectively.

In this presentation, we will provide an overview of how physiological life is made possible by control, and demonstrate the usefulness of a control engineering perspective of pathologies for diagnosis, design, and implementation of effective treatments. The concepts and principles will be illustrated using three specific examples with significant research and clinical implications: Ca++ Regulation (see Fig 1); TGF-β and prostate cancer; and Platelet Deficiency Control.


报告人介绍:

Babatunde A. Ogunnaike教授于2009年当选为美国化学工程师学会(AIChE) Fellow,2012年当选为美国国家工程院院士和尼日利亚国家工程院院士,2015年当选为美国国家发明家科学院院士,2016年当选为美国科学促进会(AAAS) Fellow。Ogunnaike教授早年就职于美国杜邦公司,任研究发展中心高级研究员,2003年全职加入特拉华大学,现任美国特拉华大学工程学院院长,化学工程William L. Friend首席教授。Babatunde A. Ogunnaike教授是化工、生物等过程控制领域的顶级专家,在复杂系统动态的深层动态行为分析、创新性设计、操作控制与优化等方面都取得了突出的成绩,其中所涉猎的复杂系统范围非常广泛,从宏观尺度下的聚合反应过程、纳米复合材料生产过程、注塑机、太阳能电动汽车到微观尺度下的细胞级或生理级的生物反应过程。发表国际学术论文300余篇,其中国际期刊论文100余篇;获得多项国际期刊最佳论文奖、国际会议最佳论文奖,并多次受邀在各种国际会议中做大会主题报告。Babatunde A. Ogunnaike教授还出版了五部专著,其中《Process Dynamics, Modeling and Control》和《Random Phenomena: Fundamentals of Probability and Statistics for Engineers》两部专著作被美国各大学作为化学工程专业教材广泛使用,并获得高度评价。


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